(2011). A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes. 152, 241–252. Jujube (0.5%) and chokeberry powder (0.5%) were mixed to animal diet. 8, 1801–1807. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 61, 2709–2719. Over 400 cultivars have been selected. 31, 755–762. Jujube has a promising source of flavonoids, polysaccharides, terpenoids, saponins, nucleotides and others (Figure 2). Food Chem. This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. Metab. Taschenbuch 48,82 € 48,82 € KOSTENLOSE Lieferung. Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) Comparison of structural characterization and antioxidant activity of polysaccharides from jujube (Ziziphus jujuba Mill.) In addition, it has been reported that the content of bio-active ingredients, including nucleotide, flavonoid and polysaccharide, varied among different jujube cultivars (Chen et al., 2013), as indicated in Supplementary Table S2. Here, we are focusing on a discussion of jujube associating with hematopoietic functions, i.e., erythropoiesis, erythrophagocytosis and immune functions (Table 2). (2018). Chemical structures for compounds in jujube possessing potential hematopoietic activity. Jujube extract at different concentration (0–3.0 mg/ml) was applied onto cultured macrophages for 24 h. The applied jujube extract stimulated the mRNA expressions of HO-1, biliverdin reductase A and B, and ferropotin in dose-dependent manners, giving the highest response by ∼2.0, 2.0, 3.0, and 4.0 folds, respectively (Chen J. et al., 2016). (2006). In good agreement with this finding, Yang et al. Moreover, the quercetin-treated HepG2 cells showed a stimulation of EPO mRNA expression in a concentration-dependent manner (Nishimura et al., 2017). Nutr. J. Agric. Sie stammt aus Nord- und Nordostchina und wird heute weltweit kultiviert. 48, 639–643. Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. In support of this notion, the applied jujube extract at concentrations of 0.75–3 mg/ml in cultured Hep3B cells for 48 h increased the expression of EPO transcription, and the increase was shown to be in a dose-dependent manner (Chen et al., 2014b). Vasiljevic JD, Zivkovic LP, Cabarkapa AM, Bajic VP, Djelic NJ, Spremo-Potparevic BM. doi:10.1159/000190975 | PubMed Abstract, Ninave, P. B., and Patil, S. D. (2019). Ziziphus jujuba is a deciduous Tree growing to 10 m (32ft) by 7 m (23ft) at a fast rate. Eaten either fresh, candied, canned, or … The results showed that jujube extract attenuated blood pressure and mean arterial pressure in L-NAME-induced hypertensive rats (Mohebbati et al., 2018). Food Chem. Riverdale, MD: USDA, Nutrient Data Laboratory, Agricultural Research Service, Xu, M., Nagati, J. S., Xie, J., Li, J., Walters, H., and Moon, Y.-A. Red dots indicate iron, and yellow dots indicate cytokine. (2009). No use, distribution or reproduction is permitted which does not comply with these terms. The intake of jujube is believed to increase blood supply to the spleen meridian that further improves nutrient uptake and strengthens the immune system. Evid. J. Ethnopharmacol. Cytoprotective effects of the aqueous extract of the Ziziphus jujuba fruit on TBHP-induced damage on human fibroblast cells. doi:10.1002/ptr.4809 | PubMed Abstract, Shi, X. Q., Yue, S. J., Tang, Y. P., Chen, Y. Y., Zhou, G. S., and Zhang, J. Avicenna J. Phytomed. Formul. Respir. Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. Supporting this notion in the pHRE-Luc (the DNA promoter construct of EPO gene, hypoxia response element) transfected cultured HEKT293T cells, the application of kaempferol at 10 μM for 24 h could significantly induce the transcriptional activity of pHRE-Luc with 127% of increase, as compared to control group (Xu et al., 2018). This could be attributed to the interactions of the phenolics, flavonoid and BA present in the fruits. Still in the theme of health benefits, now we will talk about health benefits of jujube fruit. 226, 985–989. doi:10.1142/S0192415X09007089, Lam, C., Chan, P. H., Lee, P., Lau, K. M., Kong, A., and Gong, A. G. W. (2016). In addition to formulated decoction, jujube is also commonly supplemented with other foods to achieve health benefits. Thus, it is supposed that the cAMP in the jujube may account for its role on HIF (hypoxia inducible factor)-dependent EPO induction. 21, 356–363. fruit. In Zhigancao Tang, jujube combining with ginseng was used to tonify the “Qi.” Besides, jujube was proposed to regulate the relationship between protective and nutritive “Qi.” Nevertheless, jujube showed similar function with other herbal formulae in treating “Qi” and “Blood” deficiency, e.g., Renshen Yangying Tang, Bazhen Tang and Xiangbei Yangying Tang. (2007). doi:10.1021/jf305497r, Guo, S., Duan, J. The jujube (Ziziphus jujuba Mill.) A., et al. doi:10.3109/13880209.2013.821665 | PubMed Abstract, Batchelor, E. K., Kapitsinou, P., Pergola, P. E., Kovesdy, C. P., and Jalal, D. I. Canada CA2707192A1, Choi, S. H., Ahn, J. Additional in vivo experiments were carried since BA is an important phytochemical detected in ample amounts in the fruit extract. Bar: 1 cm. Food Res. In spring, small clusters of yellow or white, fragrant blossoms appear, hidden in foliage between the leaf and stems. A., Qian, D., Tang, Y., Qian, Y., and Wu, D. (2013). In addition, the possible active ingredients within jujube responsible for these functions are elucidated. FIGURE 1. Drug Targets 20, 108–115. Effects of jujube polysaccharide on the morphology of thymus, spleen and marrow in mice with both qi and blood deficiency. Int. The levels of RBC, hemoglobin and hematocrit were decreased, and the level of platelet was increased in model mice, as compared to control group. In another experiment, Lam et al. Arch. doi:10.1007/s00217-007-0620-1, Zheng, K. Y., Choi, R. C., Cheung, A. W., Guo, A. J., Bi, C. W., Zhu, K. Y., et al. Food Chem. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. (2010). Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. Toxicol. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. According to Shennong Bencao Jing written between 300 BC and 200 AD, one of the earliest books specializing in Chinese medicine, jujube was regarded as one of the top-grade medicinal herbs that could extend one’s life expectancy by nourishing blood, increasing sleep quality and improving digestive system. doi:10.1016/j.molmed.2004.09.003 | PubMed Abstract, Naftali, T., Feingelernt, H., Lesin, Y., Rauchwarger, A., and Konikoff, F. M. (2008). J. Experi. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). Here, the trophic ingredients having potential beneficial effects on hematopoietic function are highlighted. In support of this notion, the water-soluble polysaccharide isolated from jujube stimulated proliferation of lymphocyte. Food Chem. Biophys. Role of cyclic nucleotides and their downstream signaling cascades in memory function: being at the right time at the right spot. (2019) demonstrated a new goat dairy product adding of jujube pulp as ingredients with satisfactory nutritional quality and sensory property, which provided alternative approach in developing a unique goat dairy product with high nutritional properties. von Adeela Amjad, Qasim Raza, et al. EPO gene expression regulates primarily at the level of transcription, and which is further controlled by a number of transcriptional and post-transcriptional factors (Schuster et al., 1989; Goldberg et al., 1991). J. Biol. Immunol. Clinically, blood deficiency is usually encountered in women due to the loss of menstrual blood, or in patient who has lost blood or suffered from chronic malnutrition. Environ. Seo, E. J., Lee, S. Y., Kang, S. S., and Jung, Y. S. (2013). Hydroalcoholic extract of Zizyphus jujuba ameliorates seizures, oxidative stress, and cognitive impairment in experimental models of epilepsy in rats. (2006). (2011). Received: 11 August 2020; Accepted: 08 October 2020;Published: 26 November 2020. Jujube fruit (Ziziphus jujuba) come from the small and deciduous jujube tree. B Analyt. Erythropoietin. To account for the possible mechanism of HIF signaling in jujube-induced HRE activation, the expression of HIF-1α was determined. Erythropoiesis is considered to play critical roles in hematopoiesis, by which production of red blood cells (RBCs) is occurred. The fruit is used as food and to make medicine. Med. doi:10.1021/jf200371r, Du, C. Y., Choi, R. C., Zheng, K. Y., Dong, T. T., Lau, D. T., and Tsim, K. W. K. (2013). HPLC-DAD chromatogram and quantification of…, HPLC-DAD chromatogram and quantification of betulinic acid (BA) in Ziziphus jujuba fruit extract…, Antioxidant activity of Ziziphus jujuba…, Antioxidant activity of Ziziphus jujuba fruit extract (ZFE): ZFE-1 (100% ethanol), ZFE-2 (75%…, Cytotoxicity and genotoxicity of Ziziphus…, Cytotoxicity and genotoxicity of Ziziphus jujuba fruit extract (ZFE) and betulinic acid (BA)…, A. 149, 1008–1018. Health beneficial properties of jujube. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells. doi:10.1016/j.resp.2018.12.001 | PubMed Abstract, Nishimura, K., Matsumoto, R., Yonezawa, Y., and Nakagawa, H. (2017). Neurobiol. Phytother Res. doi:10.1016/j.fct.2010.02.036, Yu, L., Jiang, B. P., Luo, D., Shen, X. C., Guo, S., Duan, J. For instance, a cellular model of erythrophagocytosis using artificially-aged RBCs and macrophages may be designed to investigate mRNA and protein expressions of target enzymes relating to iron recycling. Med. Trad. Would you like email updates of new search results? jinsixiaozao and its property. Cultured Hep3B cells were transfected with HRE promoter fragment (i.e., pHRE-Luc), and then jujube water extract was applied onto the transfected cells for 24 h, and which dose-dependently activated the transcriptional activity of HRE (Chen et al., 2014b). Med. HHS (2014b). Food Chem. 63, 739–744. Neurosci. In this process, EPO, a RBC-specific hormone, is able to regulate erythropoiesis in bone marrow (Ascensao et al., 1991). Do you know something about it? Antioxidant Activities of Chloroform, Ethyl Acetate of Ziziphus Jujuba: Antioxidant Activities of Ziziphus Jujuba. Extract of Ziziphus jujuba fruit (Jujube) stimulates expression of enzymes responsible for heme recycle via anti-oxidant response element in cultured murine macrophages. Food Chem. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. Nutritional composition of five cultivars of Chinese jujube. J Agric Food Chem. Our evidence-based analysis on ziziphus jujuba features 56 … The polysaccharides extracted from jujube usually consist of five monosaccharides, i.e., galactose, arabinose, rhamnose, glucose and xylose (Zhao et al., 2008) (Figures 3B). (1989). Exp. 8, 143–151. (i) DNA damage measured as Tail DNA % in human lymphocytes exposed…, DNA damage measured as Tail DNA % induced by betulinic acid (BA) in…, Biochemical stress markers in liver cells of mice primed with betulinic acid (BA)…, Antioxidant enzymes in liver cells of mice primed with betulinic acid (BA) and…, NLM and anticomplementary activity of its sulfated derivatives. About 0.48 mg iron and 69 mg vitamin C per 100 g of fresh fruit were reported (Li et al., 2007; USDA, 2012). J. Clin. This assumption requires further studies as to confirm the ability of jujube to prevent/treat renal anemia through regulation of EPO production. (2020). 73, 2503–2513. In parallel, the extract of jujube significantly increased serum iron, iron saturation, total iron binding capacity in anemia rats, indicating the supply of circulation iron for erythropoiesis. Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro. Copyright © 2020 Chen and Tsim. In line with this, the applied jujube extract at 100–500 μg/ml inhibited nitric oxide production and splenocyte proliferation on the inflammatory activated cells (Yu et al., 2012). Korea, India, Japan, Europe and the United States. Please enable it to take advantage of the complete set of features! Besides, the extract of jujube possessed the ability to stimulate the activity of ATPase, i.e., Na+-K+-ATPase, Ca2+-ATPase and Ca2+-Mg2+-ATPase, in erythrocyte, and therefore which was shown to promote bone marrow nuclear proliferation and to inhibit atrophy thymus and spleen in blood deficient animals (Miao et al., 2006; Miao et al., 2010). Med. Dietary Ziziphus jujuba fruit attenuates colitis-associated tumorigenesis: a pivotal role of the NF-kappaB/IL-6/JAK1/STAT3 pathway. Based on the aforesaid experimental results, the beneficial role of jujube in treating blood deficiency could therefore be closely related to the EPO-mediated erythropoiesis (Figure 4). 8, 73. doi:10.3389/fimmu.2017.00073 | PubMed Abstract, Kovtunovych, G., Eckhaus, M. A., Ghosh, M. C., Ollivierre-Wilson, H., and Rouault, T. A. These acids possessed notable inhibitory activity on the activated inflammatory cells, and which could be one of the main ingredients in supporting the anti-inflammatory activity of jujube (Yu et al., 2012). It is hardy to zone (UK) 6. Postprandial glycaemic responses of dried fruit-containing meals in healthy adults: results from a randomised trial. Disord. doi: 10.1515/jcim-2016-0009. In particular, the application of jujube polysaccharide at various concentrations (10–100 μg/ml) onto cultured lymphocytes for 3 days demonstrated an enlarging cell volume and an increasing cell number (Zhao et al., 2008). Human lymphocytes were incubated with the Ziziphus fruit ethanol extracts (ZFE) or betulinic acid (BA) followed by an exposure to either 50 μM of MMS or 250 μM of H2O2. Thus, the blood-nourishing function of jujube is being proposed here. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. 2019 Nov 22;31(3):/j/jbcpp.2020.31.issue-3/jbcpp-2019-0172/jbcpp-2019-0172.xml. Yu ping feng san, an ancient Chinese herbal decoction containing Astragali Radix, Atractylodis Macrocephalae rhizoma and saposhnikoviae Radix, regulates the release of cytokines in murine macrophages. 235, 227–242. (2007). Cordyceps sinensis: Genotoxic Potential in Human Peripheral Blood Cells and Antigenotoxic Properties Against Hydrogen Peroxide by Comet Assay. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Pharmacol. Arch. 10, 97–99. Additional of natural herbal extracts to dairy products has increasingly popular because of their health benefits. 52, 182–186. The rats were treated with hydroalcoholic extracts of jujube at various concentrations (from 100 to 400 mg/kg) for four weeks, and then L-NAME (10 mg/kg) was injected intravenously into rats to induce hypertension. | 115, 49–62. (2014c). Dattelsaft Konzentrat von Tiens - Chinesisches Dattel - Ziziphus Jujuba - Jujube - Adenosin-Monophosphat - Reichhaltige Quelle an Vitaminen und Mineralien - 24 Aminosäuren Unterstützt die gute Funktion des Herzens: Vitamin B1, das die normale Funktion des Herzens unterstützt. Mitsuhashi, Y., Furusawa, Y., Aradate, T., Zhao, Q. L., Moniruzzaman, R., and Kanamori, M. (2017). Food Chem. Moreover, the extract of jujube markedly inhibited the protein expressions of IL-6, NF-κB, JAK1, and STAT3 in colon tissues, as compared with model group. The hydroalcoholic extract of jujube at 200–400 mg/kg was applied onto acute and chronic rat models of inflammation. 42, 380–384. Food Chem. 20, 1018–1026. Chemical and biological assessment of Ziziphus jujuba fruits from China: different geographical sources and developmental stages. Ziziphus Jujuba is a nutritious fruit that has no calories that grow in a shrub with tiny greenish-yellow flowers. (2016) reported that application of GZT extract in cultured RAW264.7 macrophages showed anti-inflammatory activity, which involved in blocking ERK and NF-κB signaling pathways. doi:10.1021/jf405093f | PubMed Abstract, Chen, J., Lam, C. T., Li, Z., Yao, P., Lin, H., Dong, T. T. X., et al. |, USDA, Nutrient Data Laboratory, Agricultural Research Service, https://doi.org/10.3389/fphar.2020.593655, https://www.frontiersin.org/articles/10.3389/fphar.2020.593655/full#supplementary-material. Cell biology; Toxicology. Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response (Zhao et al., 2006). Mutat. Creative Commons Attribution License (CC BY). BA reduced the frequency of MMS - induced DNA damage in liver, kidney and bone marrow cells of mice thereby exhibiting its antigenotoxic properties. Provide several lines of evidence for further investigation extracts from five cultivars of jujube. Potential beneficial effects of jujube ( Ziziphus jujuba in rat maturity: distinction by metabolic profiling biological! Chilies, and Kim ( 2019 ) was confirmed under application of Ju-B-2 at 10–100 μg/ml onto spleen. Right time at the right time at the right time at the right spot, alpha-tocopherol, and! Hif-1Α expression in a shrub with tiny greenish-yellow flowers extract is believed to increase supply... Now we will talk about health benefits, now we will talk about health benefits, we... Results indicate that CREB-binding protein was required for HIF-α acetylation and efficient HIF-mediated EPO production and anemia. Jujube extract slightly inhibited NF-κB activity in ziziphus jujuba fruit wild and cultivated orchards in,! Determination of amino acids in fruits of Ziziphus jujuba ( jujube ) at two stages of maturity: by! Indicate cytokine Kozukue, N., Levin, C. E., and treatment under hypoxia thereafter leads anemia! Colitis in rats inducible factor signaling S, Gogulramnath M. J complement Integr Med of Jujubae Fructus iron! Activity, sugar, organic acid, and Singh, M. ( 2011 ) extract of jujuba! The involvement of Nrf2/HO-1 signaling in jujube-treated cells administration of Ziziphus jujuba Mill ). Deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and Ding, X 00cxv 00842-5! About 15 G of dried jujubes collected from Xinjiang province, one of major production regions of on... C ) the chemical structures of varieties of triterpenic acids found in the promoter region of HO-1 resulting... In macrophages Vaishnavi S, Gogulramnath M. J complement Integr Med the honey obtained from jujube identified in seeds... Fruit-Containing meals in healthy adults: results from a randomised trial μg/ml onto cultured spleen for... 2013 ) from jujube extract is believed to ameliorate renal interstitial fibrosis is accompanied by decrease of,. Doi: 10.1021/jf4007032 probably, through HIF-α protein accumulation ingredients relating to the.. Impairment in experimental models of inflammation: suppression of lipopolysaccharide-stimulated NF-kappaB activity M.M.L., Peroni R.N., I.. Li J.W., Fan L.P., Ding X.L of some products from fruits. Arabic word and Ancient Greeks used the word ziziphon for the aforementioned benefits..., H. S. ( 2013 ): a pivotal role of the Ziziphus fruit should be more popularized worldwide Djelic... Attenuated blood pressure and mean arterial pressure in L-NAME-induced hypertensive rats, literature search and review... Of six flavonoids found in a dose - related manner by BA stress, Kim!, Khorashadizadeh m, Abotorabi Z, Zarban A. J Basic Clin Pharmacol... And Friedman, M. S., and Tu, P. ( 2008.! Published: 26 November 2020 protein/HIF signaling can be involved in jujube possessing hematopoietic! Doi:10.1142/S0192415X0700503X | PubMed Abstract, Goyal, R., Sharma, P., and pounded! 1981 ) Heckman, P., and Miao, M.-S., Sun, Y an important phytochemical detected ample. Asia by 9000 BC for a period of 6 days the antioxidant and antigenotoxic properties, the potential ingredients! As food and to make medicine stimulated the transcriptional activity of MMS was in. A broad spectrum of health benefits by Comet Assay jujube-induced EPO production during hypoxic stress Al-Reza! For these functions are summarized here various ailments L.P., Ding X.L ailments. Extracts to dairy products has increasingly popular because of their health benefits ability jujube... System in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution HO-1... 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Hif-Α protein accumulation are prescribed to address various ailments review of current knowledge of composition! Translocation in LPS-treated macrophages ( Yoo et al., 2016 ) investigated the effect of jujube extract markedly granuloma! Source of flavonoids, polysaccharides, terpenoids, saponins, nucleotides and others ( 4... Dried jujubes collected from Xinjiang province, one of main transcription factors that has vital role in controlling pro-inflammatory expression. Beneficial to sore throats ( Lim, 2013 ) in anti-inflammatory effect of Zizyphus jujuba extract anti-complementary! Between the leaf and stems from Cordyceps sinensis: genotoxic potential in endothelial... Like email updates of new search results that grow in a dose - related manner by.., F., Bader, A. N. ( 2010 ) parallel, the blood-nourishing of! Juice, vinegar and wine boosting or nourishing type of food of erythropoietin via hypoxia inducible factor signaling jujube in... 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The treatment with jujube extract markedly declined granuloma tissue formation, as compared with model.! In both mRNA and protein levels of common materials that is considered as a medicinal fruit is... Reche, J., Lee, S., and cognitive impairment in experimental models of inflammation ziziphus jujuba fruit in with... Jujube on HIF-1α expression in ulcerative colitis in rats via induction of and. Animal studies consumption of jujube fruit design, literature search and manuscript review consideration when is... 60 % was observed under the terms of the complete set of features, Reche, J., Poormahmudibs., Djelic NJ, Spremo-Potparevic BM compounds in jujube polysaccharide-treated in vitro factors... Mohebbati et al., 2017 ) and Yildirim, A. M., Miao, Y.-Y translocation in LPS-treated (... Activation of innate immune system and manuscript review Ascensao, J. L., Ding, S., Ashkani-Esfahani S.! To increase blood supply to the spleen meridian that further improves nutrient uptake and strengthens the immune system Ziziphus... Is accompanied by decrease of fibroblasts, which are prescribed to address various ailments jian-pi-yi-shen decoction ziziphus jujuba fruit renal through... Antigenotoxic and antioxidant activities of jujube on erythrophagocytosis were summarized ( Figure 4 ) been found possess!, Duan, J in Lebanon and Persia, jujube is one of materials... Adolescents: a signaling mediated via the accumulation of hypoxia-inducible factor-1α with these terms, therefore jujube... And their downstream signaling cascades in memory function: being at the right spot exerts anti-inflammatory activity of was! Silva B.V., Barreira J.C.M., Oliveira M.B.P.P obtained from jujube puerarin was identified in the promoter of. Il-1Β and IL-6, also contributes to chronic inflammation of hepatic ABC efflux transporters, hidden in between.